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Standardization of Senescence Biomarkers: A major challenge in both the development and application of senescence-targeting therapies is the identification of reliable biomarkers that can accurately assess the presence of senescent cells and their effects.256 Current biomarkers for senescence, such as p16^INK4a, -galactosidase activity, and SASP factors, are useful in research settings, but their clinical applicability remains limited

Apoptosis is the most commonly studied type of cell death in the cuprizone model as it is well understood and easy to assess

408 Additionally, ZnT9 is the coactivator of -catenin-mediated gene transcription, 409,410 which serves as the critical event in the Wnt signaling pathway and the development and progression of colon cancer