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Unresolved questions include the tissue-specific regulation of ULK1 complexes in PCa autophagy, role of CPS1 in nucleotide metabolism, and spatiotemporal dynamics of ATF6-mediated therapy resistance, all critical for advancing precision therapies in this metabolic-death nexus

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In one sentence, the mechanism is receptor-mediated: GHRP binding to GHS-R1a activates a Gq/11-coupled phospholipase C cascade that mobilises intracellular calcium and triggers exocytosis of stored GH from the anterior pituitary, independent of hypothalamic GHRH signalling

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Postmortem Changes in Animal Carcasses and Estimation of the Postmortem Interval