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Various other studies have not reproduced such significant findings, with a meta-analysis noting that there was no significant effect size found for GPx [56,57]

Grouping and read-across approaches for risk assessment of nanomaterials

Katzenschlager R, Lees AJ

However, recurrent bouts of such inflammation and the toxic milieu that ensues, are thought to produce cumulative damage to myelin, oligodendrocytes and neurons, leading to progressive degeneration, atrophy and increasing disability, exacerbated by failure of myelin repair

If their blood pH does not adjust rapidly, the condition can develop into the life-threatening phenomenon known as altitude sickness