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Hu et al., 2007)

Unlike apoptosis, which involves caspase activation and nuclear fragmentation, ferroptosis is initiated by iron accumulation and lipid peroxidation, resulting in membrane rupture without caspase involvement ( This review aims to comprehensively analyze recent advances in understanding ferroptosis mechanisms in CHD and evaluate emerging clinical intervention strategies

Rats were randomly assigned to Sham ( n = 8), sRUPP ( n = 10), sRUPP + Fer-1 ( n = 6), and sRUPP + QCT ( n = 8) groups

For gut patients, the timeline is even faster

McKee KK, Tan CP, Palyha OC, Liu J, Feighner SD, Hreniuk DL, Smith RG, Howard AD, Van der Ploeg LH

Typical pathological signs include liver disease and pancreatic -cell failure