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This makes constant region optimization a valuable complement to variable region humanization, particularly for antibodies intended for clinical use where precise control of immune activity is critical

In essence, availability of data-derived factors that allow grouping due to 1) non-mode of action information (e.g

Whilst previous work by Nagashima et al

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Downregulation of selenoprotein mRNAs including GPX3 97 , GPX1 , and GPX4 96,98 , and Selenop 99 was observed in human and mouse OA chondrocytes

& Matsuyama, H