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Compound Chinese medicine (F1) improves spleen deficiency diarrhea by protecting the intestinal mucosa and regulating the intestinal flora

Furthermore, NADPH is replenished by the isocitrate dehydrogenase (IDH1/IDH2) branch of the citric acid cycle (TCA cycle), malic enzyme (ME1), and one-carbon metabolism (such as the folate cycle) depending on cell type or nutritional status

10.1186/s43043-021-00086-z 108

In contrast, anti-inflammatory cytokines such as IL-10 and TGF- are required for maintaining Treg identity and suppressive capacity

Fouad et al