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608 Morroniside activates the Nrf2/ARE pathway, upregulates GPX4, SLC7A11, FTH1, and FPN expression, increases GSH content, and decreases MDA and iron levels

Electronic supplementary material Additional file 1: Figure S1: Liver metabolites (scaled intensity) of supporting components in Ames dwarf and wild-type mice following 8 weeks of 0.16% (red/yellow) or 1.3% (blue/green) dietary methionine consumption

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Isoform-specific rescue of the embryonic lethal phenotype of gsr-1(tm3574) mutants, indicated that lethality is prevented by expressing the GSR-1b cytoplasmic form and not the GSR-1a mitochondrial form, demonstrating that GSR-1b is essential for embryonic development [82]