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Among the 226 patients who received cisplatin with ALIMTA, 74% received full supplementation with folic acid and vitamin B12 during study therapy, 14% were never supplemented, and 12% were partially supplemented

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The weekend break allows receptor resensitization while the consistent weekday dosing provides therapeutic benefit

World J Gastroenterol 15:47154719

Regulators have shown they are willing to proceed incrementally, product by product, while reserving the ability to escalate to systemic action where warranted

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