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Personas con enfermedades renales o hepticas deben evitar la suplementacin con carnitina sin supervisin mdica, ya que puede afectar negativamente la funcin de estos rganos

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2 Pathogenesis of IBD Since its emergence in the western world over a century ago, the epidemiology of IBD has undergone a significant shift ( 2.1 Dysbiosis of intestinal flora A reduction in the abundance and diversity of specific bacterial genera in the gut microbiota, as well as alterations in microbiota-derived metabolites, has been identified as a potential key factor in the pathogenesis of IBD ( Roseburia and Phascolarctobacterium , were markedly decreased in UC and CD patients in contrast to healthy people ( Roseburia is known for its role in promoting the generation of gut anti-inflammatory regulatory T cells ( Phascolarctobacterium metabolizes succinate to generate propionate when in co-culture with Paraprevotella ( Phascolarctobacterium populations in IBD patients may impair the production of propionate, thus diminishing the anti-inflammatory effects of SCFAs and contributing to the exacerbation of IBD symptoms

Keshavarz-Bahaghighat H, Sepand MR, Ghahremani MH, Aghsami M, Sanadgol N, Omidi A, Bodaghi-Namileh V, Sabzevari O (2018) Acetyl-L-Carnitine attenuates Arsenic-Induced oxidative stress and hippocampal mitochondrial dysfunction