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We have completed a proof-of-concept pilot study using this drug combination in children with severe TBIthe Pro-NAC Trial (ClinicalTrials.gov NCT01322009)

Mechanistic modeling of the MAT2ASRFPARN axis reveals a SAM-independent pathway that stabilizes SRF, drives glycolysis through PI3K/AKT activation, and promotes osteosarcoma progression, highlighting MAT2A as a therapeutic target.

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