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Ferroptosis is regulated by many aspects of iron metabolism, including iron absorption, transport, storage, and utilization (section 4.1) [17]

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Crizotinib, an ALK/ROS1/MET inhibitor, is an FDA-approved targeted agent for the treatment of advanced ROS1-rearranged NSCLC, and studies have shown that some ALK TKIs have dual inhibitory activity against ALK and ROS1 [44]