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This review delineates the molecular basis of ferroptosis sensitivity in resistant cancers, explores immune-ferroptosis crosstalk, evaluates combination strategies with immunotherapy, and discusses challenges such as toxicity and patient stratification to advance clinical translation

References Ostrom QT, Patil N, Cioffi G, Waite K, Kruchko C, Barnholtz-Sloan JS

Some clinical trials testing formulations that included N-acetylcysteine have found modest improvements in cognitive function, but clinical trials testing it alone have shown less robust results

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Daly et al

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