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GLP1R SNPs are associated with AUD in Caucasian and African American subjects, with an association between rs6923761 and AUD observed in an independent cohort of male subjects

75 Nonetheless, a subset of patients with coexisting obesity and hypertension may still derive benefit from modest BP reductions achieved with GLP-1 RAs

"Semaglutide is FDA-approved as Wegovy for chronic weight management in individuals with or without diabetes," explains Dr

Frontiers in Endocrinology (2023) This comprehensive review looked at 39 different studies to understand how GLP-1 medications and another type of diabetes medication, SGLT2 inhibitors, affect pregnancy and breastfeeding

Systemic GLP-1 receptor deficiency impairs GLP-1-induced anorexia as anticipated.41 However, these mice do not display alterations in baseline body weight, suggesting that GLP-1 receptor is not critical for body weight regulation under basal conditions.41 Notably, subsequent investigations revealed that both male and female mice lacking systemic GLP-1 receptor are resistant to diet-induced obesity.39,42 Focusing on central mechanisms, intracerebroventricular administration of GLP-1 failed to modulate feeding behavior in GLP-1 receptor global knockout mice.41 Central inhibition of GLP-1 receptor disrupts glucose homeostasis and reduces food intake, whereas peripheral GLP-1 receptor inactivation impairs glucose-stimulated insulin secretion, diminishes glucose clearance, elevates glucagon levels, and accelerates gastric emptying