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Seminal randomized controlled trials by Creagan and Moertel administering oral VC (10 g/day) failed to replicate Camerons reported survival benefits in terminal cancer patients, casting doubt on VCs clinical utility ( 2 O 2 generation ( KRAS )-mutant tumor regression, lower doses (510 mM) paradoxically enhance glutathione synthesis in 32% of glioblastoma cases ( TET1 ) -mediated MMP-9 downregulation, yet population studies associate supplemental VC with 1.3-fold increased recurrence risk in ER + breast cancer ( In this review, we synthesize mechanistic insights from redox biology and immunometabolism with clinical trial data to propose a framework for optimizing VC-based combination therapies (Graphical abstract)

When a lump lasts longer than expected, becomes painful, or changes in appearance, other causes (such as prolonged inflammation or, more rarely, infection) should be considered

Forebrain deletion of GDI in adult mice worsens the pre-synaptic deficit at cortico-lateral amygdala synaptic connections

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Surfactant-stable and pH-sensitive liposomes coated with N-succinyl-chitosan and chitooligosaccharide for delivery of Quercetin

Stability of glucagon-like peptide 1 and glucagon in human plasma. Endocrine Connections , 2015
