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Description
The field is now evolving through novel strategies, including bispecific CAR-T cells targeting CD19 and CD22, as well as CD38-specific CAR-T cells, which aim to increase therapeutic efficacy by countering mechanisms such as antigen escape [68, 69]

Ye Y, et al

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& Ravel, J
Major issues include low oral bioavailability, complex in vivo metabolism, and substantial patient variability, which can significantly influence therapeutic efficacy

In contrast, inhibition of CD38 exoenzymatic activity using the Ab68 mAb reduced the production of ADPR (43)
