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Standard topical application struggles to get peptides through the skin barrier

Increased numbers of activated neutrophils are found in sputum and bronchoalveolar lavage (BAL) fluid of patients with COPD 4,5,8,9 , although the role of neutrophils in COPD is not yet clear

For patients on these medications, high-dose oral supplementation or injections are clinically necessary to bypass the digestive blockade

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