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Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols

GATA1 is the key transcription factor for erythropoiesis, controlling the expression of a large series of erythroid genes, including erythropoietin receptor, globins and several membrane proteins.20 GATA1-deficient mice die in utero due to severe anemia at embryonic day 10.5-11.5,21 and chimeric mice lacking GATA1 fail to produce mature red blood cells, although the formation of cells of other hematopoietic lineages is normal.22 In contrast, overexpression of GATA1 in erythroid cells inhibits their differentiation, leading to fatal anemia in mice.23 GATA1 stability is finely regulated by multiple mechanisms,24 since changes in its protein levels will exert a great influence on erythropoiesis
