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2016).The exact pathophysiology of PD is likely multifactorial amongst which oxidative stress, neuroinflammation and mitochondrial dysfunction may play a role in the development and progression of PD

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The mitochondrial response to DNA damage

doi: 10.1016/j.semcdb.2014.02.012 69 Martino-AndradeAJChahoudI

Darkening initially started on the palms and feet [Figure - 1] and then gradually involved the face, gums and tongue