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Upon entering the mouth, approximately 20% of dietary nitrate is immediately converted to nitrite by commensal facultative anaerobic bacteria found under the tongue ( Stimulation of NO production via the NOS-independent pathway Although several investigations have provided insight into the impact of the NOS-independent pathway, research has yet to reveal the specific stimuli required to initiate this pathway ( Exercise as a stimulant for NO production via the NOS-independent pathway The two conditions mentioned above (hypoxia and/or acidosis) commonly occur with high-intensity and intermittent exercise ( Functions of NO in the vasculature Once synthesized, NO is involved in several physiological functions

FIGURE 2 On the other hand, in addition to its well-known functions, PGC1, a master regulator of mitochondrial biogenesis, positively regulates mitophagy by directly inducing the expression of transcription factor EB (TFEB) that mediates lysosomal biogenesis (Settembre et al., 2011)

Proc Natl Acad Sci U S A 92(4):983987 Cline GW, Petersen KF, Krssak M et al (1999) Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes

[DOI] [PubMed] [Google Scholar] 440.Xu Y, Twarog M, Li N, Banks A, Schustak J, Bao Y, et al

Department of Health, Education, and Welfare

Meanwhile, as key metabolites of traditional Chinese medicines A