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Noteworthy, deletion of GluN1 also causes reduced expression of the transcriptional coactivator PGC1-alpha, which is highly expressed in PV interneurons and is a positive regulator of the expression of genes implicated in mitochondrial function and antioxidant defence [131]

[Google Scholar] [PubMed] [CrossRef] Lang A, Salomon N, Wu JC, Kopylov U, Lahat A et al

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In addition, curcumin intakes ranging from 0.45 to 3.6 g/day for up to four months did not increase leukocyte GST activity in humans (9)

Sporadic use does not

Conclusion In toto, the findings of this study confirmed the neuroprotective effects of FD by demonstrating that this plant significantly enhances spatial learning and memory, attenuates neurodegeneration and increases the number of viable granule neurons in the hippocampal subregion in D-gal and AlCl 3 -induced AD rats