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Multiple drug transporters contribute to the brain transfer of levofloxacin

Schmidt R, Ropele S, Pendl B, Ofner P, Enzinger C, Schmidt H, et al

113 It was then fused to the constant region (Fc) of modified human immunoglobulin G4 (IgG4) via a -(Gly-Gly-Gly-Gly-Ser) 3-Ala- bridge and exhibits an average biological half-life of 90 h

AAPS PharmSciTech article 102 8

Both of the above used common animal models are known as being indicative for human disturbances and their therapy
