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Melatonin functions as a hormone, synchronizing the circadian rhythms of many organs and their functions (Tiwari et al., 2021)
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As noted by Kraus et al., Nature Medicine , NNMT inhibition in white adipose tissue significantly increased energy expenditure and reduced fat mass in animal models without changes to diet or activity
Animal studies show that mice prone to obesity have high NNMT levels in their white fat tissue