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Where a deficiency is suspected but serum levels are normal, other markers can be used to confirm a deficiency

Yes, this is known as seronegative autoimmune thyroiditis, or serum-negative Hashimotos

However, oxygen is incredibly toxic in excess, and the mitochondria serve a critical function in coupling its detoxification to the generation of energy 63

Current British Society of Gastroenterology guidance suggests considering a baseline upper GI endoscopy with biopsies in adults aged 50 or over with confirmed pernicious anaemia to document autoimmune gastritis

The last involves oxygen reduction and is a process that can act to balance chloroplast ATP:NADPH ratios or function as an alternative sink for electrons but which also generates ROS as intermediates (Allen and Hall 1974