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Indeed, high extracellular concentrations of glutamate inhibit system x c - and induce ferroptosis, perhaps explaining toxic effects of glutamate when it accumulates to high concentrations in the nervous system (Dixon et al., 2012)

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doi: 10.1016/j.cbi.2021.109625 59 DzydzanOBrodyakIStrugaa-DanakPStrachAKucharskaAZGabrielskaJet al