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Lower GSH leads to faster tissue damage

Compound 38 can also be reduced to amine 40 , which facilitates the attachment of the linker to the carboxylic acid terminal via the formation of an amide bond (41) (Scheme 6) 81,83

This implies that a well-designed nano-shell can limit oxygen access to the oil core

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470 In animal models of Apelin-13-caused cardiomyocyte hypertrophy and heart failure, NCOA4-activated ferritinophagy leads to the upregulation of SFXN1 expression, causing mitochondrial iron overload and mitochondrial ROS overproduction, increased lipid peroxidation, and ultimately, ferroptosis