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Compared to precancerous polyps and normal tissues, the demethylation of the NRF2 promoter is significantly increased in tumor tissues, leading to NRF2 overexpression and promoting tumor progression

10.2174/138945010791170842 119 YangJ.JiaZ.ZhangJ.PanX.WeiY.MaS.et al (2022a)

Additionally, energy production was impaired and ROS production was decreased

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Mitochondrial dysfunction contributes to PD by impairing respiratory chain function, leading to reduced ATP production and increased ROS generation, resulting in oxidative stress and subsequent neuronal damage (Henrich et al