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Ekstrapolacja z bada na szczurach gdzie dawki byy proporcjonalnie znacznie wysze w przeliczeniu na kilogram masy ciaa

Normal erectile function involves 3 synergistic and simultaneous processes : 1) neurologically mediated increase in penile arterial inflow, 2) relaxation of cavernosal smooth muscle and 3) restriction of venous outflow from the penis

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Additionally, similar to the inhibition of cuproptosis by the glycolytic effect of FLS, effector T cells exert their effect through the mTOR-dependent pathway, using glycolysis to take in large amounts of glutamine and glucose to provide energy, which may also inhibit cuproptosis, thereby exerting a pro-inflammatory effect

Preclinical models demonstrate that sirolimus reduces renal collagen IV deposition and suppresses VEGF-induced glomerular hypertrophy in diabetic rats (149)