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Compromised detoxification processes, leading to toxin accumulation

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After ferroptosis, excess intracellular free iron can enter the mitochondria, resulting in smaller myocardial mitochondria, increased mitochondrial membrane density, decreased mitochondrial respiration, and mitochondrial membrane potential depolarization (Sumneang et al., 2020), thus inducing CD and a series of Cardiac Diseases such as arrhythmia (Hu et al., 2021)

doi:10.22074/ijfs.2018.5142 67 Cheraghi, E., Mehranjani, M

[DOI] [PubMed] [Google Scholar] 69.Quenelle DC, Collins DJ, Wan WB, Beadle JR, Hostetler KY, Kern ER