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H 2 O 2 can cross membranes in the cochlea and oxidize different parts of the cell

Follistatin (FST) is a glycoprotein predominantly secreted by the liver and expressed in various tissues, functioning to inhibit TGF- superfamily members

doi: 10.7150/ijms.12177

Rajasekharan, P.E., and S

Inhibiting system X c with compounds such as sorafenib and sulfasalazine can promote ferroptosis, while overexpression of system X c components by contrast is capable of diminishing erastin-induced ferroptosis [23]

Given that the cellular thiol network, including GSH, involves crosstalk between the cytosol and organelles, we selected two of the dysregulated enzymes, which had been identified by 2D electrophoresis, with important roles in mitochondrial function, i.e., Aco2 and mitochondrial creatine kinase (mtCK) (Fig