fda warning bpc-157 peptide not approved drug FDA's Overreach on Compounded Peptides What are peptides and why
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the .2% loss occurs in those with pernicious anemia (5) (see below for an explanation of pernicious anemia)

However, for anyone with absorption issues (like pernicious anemia or IBD), oral supplements are often insufficient

Certain medications, such as proton pump inhibitors and metformin, can deplete vitamin B12 in the body and lead to an increased requirement