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Every year, over a third of smokers attempt to quit, but only about 3% succeed ( Nicotine dependence can be defined as a pattern of psychological attributes that result in the compulsive and repetitive search for, and use of, nicotine (Schilstrm et al., 1997

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At the biochemical level, NNMT regulates the conversion of nicotinic acid (NA) into 1-methylnicotinamide (1-MNA)