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Description
The areas of peaks corresponding to DHT and testosterone were integrated
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Although, zopolrestat and tolrestat were discontinued due to severe hepatotoxicity and an unfavorable risk-benefit profile observed in phase 2 and phase 3 clinical trials, respectively [150,151,152], and ranirestat, which also progressed through phase 3 trial, focused primarily on diabetic polyneuropathy rather than cardiovascular outcomes [153]
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10.1166/jbn.2016.2207 [DOI] [PubMed] [Google Scholar] Rapti E., Adamantidi T., Efthymiopoulos P., Kyzas G