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The three receptors to which retatrutide binds function as follows: GLP-1: Enhances satiety, reduces appetite, and promotes insulin secretion, directly supporting weight loss and blood glucose regulation

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Pevec et al., 2010)), and tendon healing (Staresinic et al., 2003

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These limited reports suggest good tolerability, though the small sample sizes, lack of standardized safety monitoring, and retrospective or uncontrolled study designs limit definitive safety conclusions