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DCA and CDCA can act as metabolic danger signals and activate both signals 1 and 2 of the NLRP3 inflammasome, which increases IL-1 release, whereas LCA can suppress NLRP3 via TGR5 signaling and can reduce macrophage uptake of oxidized LDL [30]

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These effects include the destruction of hepatic sinus endothelium, CYP450 enzyme system disorder and transporter-mediated cholestasis

Binders must be taken on an empty stomach at least 1 hour before or 2 hours after meals, other supplements, and medications