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Interestingly, a randomized double-blind phase III clinical trial to evaluate elesclomol in combination with chemotherapy in patients with melanoma showed that elesclomol had stronger anti-tumor activity in patients with low plasma levels of lactate dehydrogenase 205 (Table 1)

Furthermore, the aggregation of amyloid-beta (A) plaques, which constitute the signature pathologies of AD, have been associated with ferroptosis-linked mechanisms [516]

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Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B 3rd, Stockwell BR (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death