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A study with oral dosing indicated that approx

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Most of these involve the stifle (knee) joint, where the cranial cruciate ligament, menisci, and articular cartilage work together and where the majority of canine orthopedic injuries occur: Cranial Cruciate Ligament Disease: The canine equivalent of human ACL tears, extremely common in medium to large breeds

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Excessive ROS directly oxidatively damage proteins, lipids and DNA, leading to cellular dysfunction, accelerated senescence and death, and activation of proinflammatory signaling pathways (e.g., NF-B) and catabolic pathways, forming a vicious cycle (Guo et al., 2021)
