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Disruption of circadian rhythms through exposure to LAN appears to trigger a cascade of biological effects, ranging from melatonin suppression and oxidative stress to immune dysregulation, telomere shortening, and epigenetic alterations

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Similarly, administration of Avidekel oil produced comparable transcriptional changes with pronounced changes in action potential and nerve impulse transmission pathways in the cerebellum supporting the idea of general neuromodulatory effects of the cannabinoid-based compounds [82]

Impaired kidney function significantly extends GHK-Cu clearance time

Effects of the mGluR5 antagonist MPEP on ethanol withdrawal induced anxiety-like syndrome in rats