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Saccharomyces cerevisiae RC016 reduces AFB1 bioavailability in rodent models, while other yeast strains show no detectable effect (92)

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However, after treatment with antibiotics, a considerable fraction (17%) of the dose was recovered as the sulfoxide of the mercapturate, suggesting that microbial transformations in the gut may be important routes for the metabolism of certain sulfur-containing compounds

3.4.1 Oxidative stress-endocrine axis integration ROS accumulation triggers activation of stress-activated protein kinases (JNK/p38 pathway), which subsequently inhibits AR transcriptional activity, creating a cascade that disrupts testosterone synthesis ( 3.4.2 Metabolism-immune-epigenetic crosstalk Inflammatory mediators including TNF- and NF-B activation modulate AR signaling capacity while IL-6 triggers DNA methylation changes that affect spermatogenesis ( 3.5 Emerging epigenetic mechanisms Recent investigations have revealed the critical role of non-coding RNAs and chromatin modifications in mediating EED-induced reproductive toxicity, providing new insights into both immediate and transgenerational effects