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Following the landmark report by the Zurich group we added continuous veno-venous haemofiltration and methylprednisolone to our protocol (Supporting Table 1)

In addition, tumor metabolic heterogeneity poses dual challenges where oxidative phosphorylation-dependent subpopulations evade glycolysis inhibitors, necessitating combined pathway blockade [24, 25]

In contrast, digoxin has a TI of only about 2, and for such drugs toxicity may be precipitated by relatively small changes in dosage regimen or the clearance of the drug from the body

Research shows that AOD9604 increases HSL activity in a dose-dependent manner, with higher doses producing greater lipolytic effects

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Collectively, these findings highlight the immunological duality of ferroptosis capable of either igniting tumor immunity and strengthening immune escape, depending on the prevailing microenvironmental cues (Jiang et al., 2019)