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[5] Role in detoxification of xenobiotic substances [edit] One of the primary roles of bacterial glutathione transferases is to reduce the toxic effects of xenobiotics from the cell using the phase II system of detoxification metabolism

Oncotarget (2014) 5:79823.10.18632/oncotarget.2352 36 ValenciaTKimJYAbu-BakerSMoscat-PardosJAhnCSReina-CamposMet alMetabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis

Prominent examples include oxytocin known for its positive effects on social behaviour and autism [161,162,163] as well as orexin-A improving the CNS hypocretin signalling and olfaction and thus offering a possible treatment for narcolepsy [164,165,166]

Studies conducted in recent years have shown that some anticancer and non-anticancer drugs can downregulate P-gp, enhance chemosensitivity and rescue tumor MDR