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A conservative feature for these GPx is the presence of a second or even a third cysteine residue

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729 patients) Pasquier M1, Zurron N, Weith B, et al

[23] One primary mechanism involves DNA methylation, a chemical modification where methyl groups are added to DNA, often at CpG sites (regions of DNA where a cytosine nucleotide is followed by a guanine nucleotide)

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Overall, TP53 mutations and deletions occur more frequently in pediatric B-ALL patients with relapse versus primary and correlate with inferior outcomes [349]