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Agha M, Agha R

The drugmaker said, based on its investigation, the "semaglutide" active pharmaceutical ingredients that are in the knock-off drugs sold by telehealth entities and compounding pharmacies are manufactured by foreign suppliers in China

10.1155/2016/3094642 [DOI] [PMC free article] [PubMed] [Google Scholar] 14.Rakipovski G, Rolin B, Nhr J, Klewe I, Frederiksen KS, Augustin R, Hecksher-Srensen J, Ingvorsen C, Polex-Wolf J, Knudsen LB

Patients on tirzepatide lost an average of 20.2% of their body weight over 72 weeks Patients on semaglutide lost an average of 13.7% of their body weight over the same period 47% more tirzepatide patients achieved 25% or greater body weight loss compared to semaglutide Tirzepatide also produced greater reductions in waist circumference across all dose comparisons A 2024 meta-analysis published in JAMA Internal Medicine analyzing real-world data from over 140,000 patients confirmed the same pattern: tirzepatide produced an average of 4.23 kg more weight loss than semaglutide across all doses and durations studied