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It has been declared, that neurotoxic 6-hydroxydopamine (and also superoxide radical) is able to release free iron from ferritin which in turn may participate in Fenton chemistry, forming ROS and initiating lipid peroxidation (Monteiro and Winterbourn 1989)
A recent study has demonstrated that an acute increase in the intracellular concentration of ROS inhibits the glycolytic enzyme pyruvate kinase M2 (PKM2) through the oxidation of Cys358 ( NRF2 INHIBITORS FOR ANTICANCER THERAPY Due to the multifaceted roles of Nrf2 in cancers, Nrf2 inhibitors could be effective for anticancer therapy

10.1016/j.molcel.2013.04.021 Mol

n = 16 tumours (WT) n = 10 tumours (NRF2 D29H )

Feedback-regulated enzyme activitydegradative enzyme activity increases with mucus layer thickness, whereas metabolic feedback inhibition suppresses enzyme gene expression when mucin availability is low, preventing excessive depletion [49, 50]