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When multiple publications addressed similar experimental models or clinical populations, priority was given to studies with larger sample sizes, standardized extracts, rigorous study designs, and clearly reported outcomes

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In the microenvironment of solid tumors, hypoxia has been shown to stimulate autophagy in tumor-associated blood vessels which in turn can alter metabolic pathways and surface markers of endothelial cells (Verhoeven et al., 2021)

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