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P.LoaneC.PolitisM.RoussakisA

Kansanen et al., 2013) together with the upstream mediators (dead receptors

Standard ranges fail to identify patients with subclinical vitamin B12 deficiency (which means many patients may not have full-blown symptoms of vitamin B12 deficiency but they do experience some) 3

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Peer review Peer review information Nature Metabolism thanks Timothy Wai and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Notably, the deletion of the C-terminal domain completely impairs the PC synthesis activity of the enzyme in the presence of Zn 2+ and partially inactivates PC synthesis in the Cd- or Hg-containing reactions [53, 55]