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Research Highlights Metabolic Regulation and Anti-Obesity Effects: Potent inhibition of nicotinamide N-methyltransferase (NNMT) increases cellular NAD and S-adenosylmethionine (SAM) levels, enhances polyamine flux, boosts energy expenditure, and suppresses lipogenesis

Research demonstrates that NNMT expression increases significantly with advancing age, particularly in metabolic tissues, contributing to the progressive decline in NAD+ levels observed during aging

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M., Gonzlez M
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