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Meyer et al., in vitro redox-midpoint of GCL (Hicks et al., Plant Glutathione Synthetases: Structure, Function, and Product Diversity In the second step of glutathione synthesis, GS catalyzes the ATP-dependent addition of glycine to -glutamylcysteine (Figure 1)

doi: 10.1046/j.1365-2958.2003.03737.x 13 Diez-GutirrezL.San VicenteL.BarrnL

[Abstract] Nanoscale

This metabolic safety profile makes AOD-9604 potentially suitable for individuals with metabolic syndrome or diabetes risk factors who might not tolerate traditional growth hormone therapy, though medical supervision remains appropriate

The committee's recommendation, while not binding, is heavily weighted in the agency's subsequent decision on permanent listing