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This synthetic approach is relevant when aiming to conjugate two entities to an oligonucleotide as exemplified recently in the work of Aartsma-Rus and coworkers: conjugation of a homing peptide and a cell-penetrating peptide allows for increased targeted tissue delivery of a morpholino oligomer as compared to the conjugation of a single peptide 34

This phenomenon, called aerobic glycolysis or the Warburg effect, has been exploited for visualizing tumors in the clinical setting by imaging their uptake of the radiolabeled glucose analog, [18F] fluoro-2-deoxyglucose (FDG), via Positron Emission Tomography (PET)

Sasao T, Fukuda Y, Yoshida S, Miyabara S, Kasashima Y, Kuwano A, et al

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However, there is still a lack of research to solidify this drugs position in the treatment of IBD, especially after mixed results achieved in phase 3 study (LAUREL), where contrary to earlier findings, no significant differences were observed between etrolizumab maintenance treatment and placebo for the primary endpoint of remission [58]