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Concurrently, the utilization of leriglitazone and targeting of peroxisome-proliferator-activated receptor gamma may serve as efficacious strategies to improve mitochondrial function, thus offering a therapeutic avenue for FRDA [808, 811]

qtot 0.39 43 HGA1 1 ful H43 43 0.09 1.008

Altered DNA methylation status of human brain derived neurotrophis factor gene could be useful as biomarker of depression

Table 6.1 compares the relative reactivity of a variety of common nucleophiles

Increased ROS inhibit key steroidogenic enzymes, such as the steroidogenic acute regulatory (StAR) protein and cytochrome P450 [164], resulting in impaired testosterone production [165], which in turn, leads to impaired NO synthesis [166]