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Among down-regulated DEGs, ULBP13 showed the largest decrease (logFC = 10.24), followed by F5 (8.73), ULBP21 (6.58), ULBP3 (5.92), and CCL22 (4.85)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 152.Bouranis J.A., Beaver L.M., Ho E

Its active form, 1,25(OH)2D, regulates mucosal immunity, host defense, and inflammation by binding to the vitamin D receptor (VDR) in macrophages [73, 74], triggering the expression of the antimicrobial peptide cathelicidin (CAMP) (LL-37) and promoting autophagosomelysosome fusion and maturation [16, 75]

Nanomedicine Nanomedicine and the manipulation of compounds on the nanometric scale is being investigated for the improvement of drug delivery systems, specifically to improve drug bioavailability, half-life, or achieve more sustained levels of circulation